Clinical management of the uraemic syndrome in chronic kidney disease.
Identifieur interne : 000154 ( Main/Exploration ); précédent : 000153; suivant : 000155Clinical management of the uraemic syndrome in chronic kidney disease.
Auteurs : Raymond Vanholder [Belgique] ; Denis Fouque [France] ; Griet Glorieux [Belgique] ; Gunnar H. Heine [Allemagne] ; Mehmet Kanbay [Turquie] ; Francesca Mallamaci [Italie] ; Ziad A. Massy [France] ; Alberto Ortiz [Espagne] ; Patrick Rossignol [France] ; Andrzej Wiecek [Pologne] ; Carmine Zoccali [Italie] ; Gérard Michel London [France]Source :
- The lancet. Diabetes & endocrinology [ 2213-8595 ] ; 2016.
Abstract
The clinical picture of the uraemic syndrome is a complex amalgam of accelerated ageing and organ dysfunction, which progress in parallel to chronic kidney disease. The uraemic syndrome is associated with cardiovascular disease, metabolic bone disease, inflammation, protein energy wasting, intestinal dysbiosis, anaemia, and neurological and endocrine dysfunction. In this Review, we summarise specific, modern management options for the uraemic syndrome in chronic kidney disease. Although large randomised controlled trials are scarce, based on data from randomised controlled trials and observational studies, as well as pathophysiological reasoning, a therapeutic algorithm can be developed for this complex and multifactorial condition, with interventions targeting several modifiable factors simultaneously.
DOI: 10.1016/S2213-8587(16)00033-4
PubMed: 26948372
Affiliations:
- Allemagne, Belgique, Espagne, France, Italie, Pologne, Turquie
- Communauté de Madrid, Grand Est, Lorraine (région), Île-de-France
- Madrid, Nancy, Paris, Vandœuvre-lès-Nancy
- Université Claude Bernard Lyon 1, Université de Lorraine
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Le document en format XML
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INSERM U970, Hôpital Européen Georges Pompidou, Paris.</nlm:affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Investigation Network Initiative Cardiovascular and Renal Clinical Trialists (INI-CRCT), French Clinical Research Infrastructure Network (F-CRIN), Nancy, France; INSERM U970, Hôpital Européen Georges Pompidou</wicri:orgArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="doi">10.1016/S2213-8587(16)00033-4</idno><idno type="RBID">pubmed:26948372</idno><idno type="pmid">26948372</idno><idno type="wicri:Area/PubMed/Corpus">000015</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000015</idno><idno type="wicri:Area/PubMed/Curation">000015</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000015</idno><idno type="wicri:Area/PubMed/Checkpoint">000023</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000023</idno><idno type="wicri:Area/Ncbi/Merge">000229</idno><idno type="wicri:Area/Ncbi/Curation">000221</idno><idno type="wicri:Area/Ncbi/Checkpoint">000221</idno><idno type="wicri:Area/Main/Merge">000140</idno><idno type="wicri:Area/Main/Curation">000154</idno><idno type="wicri:Area/Main/Exploration">000154</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical management of the uraemic syndrome in chronic kidney disease.</title><author><name sortKey="Vanholder, Raymond" sort="Vanholder, Raymond" uniqKey="Vanholder R" first="Raymond" last="Vanholder">Raymond Vanholder</name><affiliation wicri:level="1"><nlm:affiliation>Nephrology Section, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium. Electronic address: raymond.vanholder@ugent.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Nephrology Section, Department of Internal Medicine, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Fouque, Denis" sort="Fouque, Denis" uniqKey="Fouque D" first="Denis" last="Fouque">Denis Fouque</name><affiliation wicri:level="4"><nlm:affiliation>Department of Nephrology-Nutrition-Dialysis, Centre Hospitalier Lyon Sud, Carmen-CENS, Université Claude Bernard Lyon 1, Lyon, France; Investigation Network Initiative Cardiovascular and Renal Clinical Trialists (INI-CRCT), French Clinical Research Infrastructure Network (F-CRIN), Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Nephrology-Nutrition-Dialysis, Centre Hospitalier Lyon Sud, Carmen-CENS, Université Claude Bernard Lyon 1, Lyon, France; Investigation Network Initiative Cardiovascular and Renal Clinical Trialists (INI-CRCT), French Clinical Research Infrastructure Network (F-CRIN), Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName></affiliation></author><author><name sortKey="Glorieux, Griet" sort="Glorieux, Griet" uniqKey="Glorieux G" first="Griet" last="Glorieux">Griet Glorieux</name><affiliation wicri:level="1"><nlm:affiliation>Nephrology Section, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Nephrology Section, Department of Internal Medicine, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Heine, Gunnar H" sort="Heine, Gunnar H" uniqKey="Heine G" first="Gunnar H" last="Heine">Gunnar H. Heine</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine IV, Saarland University Medical Centre, Homburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine IV, Saarland University Medical Centre, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Kanbay, Mehmet" sort="Kanbay, Mehmet" uniqKey="Kanbay M" first="Mehmet" last="Kanbay">Mehmet Kanbay</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Mallamaci, Francesca" sort="Mallamaci, Francesca" uniqKey="Mallamaci F" first="Francesca" last="Mallamaci">Francesca Mallamaci</name><affiliation wicri:level="1"><nlm:affiliation>Nephrology, Dialysis and Transplantation Unit, and CNR-IFC Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Ospedali Riuniti, Reggio Calabria, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Nephrology, Dialysis and Transplantation Unit, and CNR-IFC Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Ospedali Riuniti, Reggio Calabria</wicri:regionArea><wicri:noRegion>Reggio Calabria</wicri:noRegion></affiliation></author><author><name sortKey="Massy, Ziad A" sort="Massy, Ziad A" uniqKey="Massy Z" first="Ziad A" last="Massy">Ziad A. Massy</name><affiliation wicri:level="1"><nlm:affiliation>Investigation Network Initiative Cardiovascular and Renal Clinical Trialists (INI-CRCT), French Clinical Research Infrastructure Network (F-CRIN), Nancy, France; Division of Nephrology, Ambroise Paré University Hospital (APHP), University of Paris Ouest, Versailles-Saint-Quentin-en-Yvelines (UVSQ), Boulogne-Billancourt, Paris, France; INSERM U1018, Research Centre in Epidemiology and Population Health (CESP), UVSQ, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Investigation Network Initiative Cardiovascular and Renal Clinical Trialists (INI-CRCT), French Clinical Research Infrastructure Network (F-CRIN), Nancy, France; Division of Nephrology, Ambroise Paré University Hospital (APHP), University of Paris Ouest, Versailles-Saint-Quentin-en-Yvelines (UVSQ), Boulogne-Billancourt, Paris, France; INSERM U1018, Research Centre in Epidemiology and Population Health (CESP), UVSQ, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Ortiz, Alberto" sort="Ortiz, Alberto" uniqKey="Ortiz A" first="Alberto" last="Ortiz">Alberto Ortiz</name><affiliation wicri:level="3"><nlm:affiliation>Division of Nephrology, IIS-Fundacion Jimenez Diaz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Division of Nephrology, IIS-Fundacion Jimenez Diaz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Rossignol, Patrick" sort="Rossignol, Patrick" uniqKey="Rossignol P" first="Patrick" last="Rossignol">Patrick Rossignol</name><affiliation wicri:level="4"><nlm:affiliation>Investigation Network Initiative Cardiovascular and Renal Clinical Trialists (INI-CRCT), French Clinical Research Infrastructure Network (F-CRIN), Nancy, France; INSERM Centre d'Investigations Cliniques (CIC)-1433, and INSERM U1116, Nancy, France; Institut Lorrain du Cœur et des Vaisseaux, CHU Nancy, Vandoeuvre lès Nancy, France; Université de Lorraine, Nancy, France; Association Lorraine pour le Traitement de l'Insuffisance Rénale, Vandoeuvre lès Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Investigation Network Initiative Cardiovascular and Renal Clinical Trialists (INI-CRCT), French Clinical Research Infrastructure Network (F-CRIN), Nancy, France; INSERM Centre d'Investigations Cliniques (CIC)-1433, and INSERM U1116, Nancy, France; Institut Lorrain du Cœur et des Vaisseaux, CHU Nancy, Vandoeuvre lès Nancy, France; Université de Lorraine, Nancy, France; Association Lorraine pour le Traitement de l'Insuffisance Rénale, Vandoeuvre lès Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Wiecek, Andrzej" sort="Wiecek, Andrzej" uniqKey="Wiecek A" first="Andrzej" last="Wiecek">Andrzej Wiecek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Zoccali, Carmine" sort="Zoccali, Carmine" uniqKey="Zoccali C" first="Carmine" last="Zoccali">Carmine Zoccali</name><affiliation wicri:level="1"><nlm:affiliation>Nephrology, Dialysis and Transplantation Unit, and CNR-IFC Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Ospedali Riuniti, Reggio Calabria, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Nephrology, Dialysis and Transplantation Unit, and CNR-IFC Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Ospedali Riuniti, Reggio Calabria</wicri:regionArea><wicri:noRegion>Reggio Calabria</wicri:noRegion></affiliation></author><author><name sortKey="London, Gerard Michel" sort="London, Gerard Michel" uniqKey="London G" first="Gérard Michel" last="London">Gérard Michel London</name><affiliation wicri:level="3"><nlm:affiliation>Investigation Network Initiative Cardiovascular and Renal Clinical Trialists (INI-CRCT), French Clinical Research Infrastructure Network (F-CRIN), Nancy, France; INSERM U970, Hôpital Européen Georges Pompidou, Paris.</nlm:affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Investigation Network Initiative Cardiovascular and Renal Clinical Trialists (INI-CRCT), French Clinical Research Infrastructure Network (F-CRIN), Nancy, France; INSERM U970, Hôpital Européen Georges Pompidou</wicri:orgArea></affiliation></author></analytic><series><title level="j">The lancet. Diabetes & endocrinology</title><idno type="eISSN">2213-8595</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The clinical picture of the uraemic syndrome is a complex amalgam of accelerated ageing and organ dysfunction, which progress in parallel to chronic kidney disease. The uraemic syndrome is associated with cardiovascular disease, metabolic bone disease, inflammation, protein energy wasting, intestinal dysbiosis, anaemia, and neurological and endocrine dysfunction. In this Review, we summarise specific, modern management options for the uraemic syndrome in chronic kidney disease. Although large randomised controlled trials are scarce, based on data from randomised controlled trials and observational studies, as well as pathophysiological reasoning, a therapeutic algorithm can be developed for this complex and multifactorial condition, with interventions targeting several modifiable factors simultaneously.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pologne</li><li>Turquie</li></country><region><li>Communauté de Madrid</li><li>Grand Est</li><li>Lorraine (région)</li><li>Île-de-France</li></region><settlement><li>Madrid</li><li>Nancy</li><li>Paris</li><li>Vandœuvre-lès-Nancy</li></settlement><orgName><li>Université Claude Bernard Lyon 1</li><li>Université de Lorraine</li></orgName></list><tree><country name="Belgique"><noRegion><name sortKey="Vanholder, Raymond" sort="Vanholder, Raymond" uniqKey="Vanholder R" first="Raymond" last="Vanholder">Raymond Vanholder</name></noRegion><name sortKey="Glorieux, Griet" sort="Glorieux, Griet" uniqKey="Glorieux G" first="Griet" last="Glorieux">Griet Glorieux</name></country><country name="France"><region name="Grand Est"><name sortKey="Fouque, Denis" sort="Fouque, Denis" uniqKey="Fouque D" first="Denis" last="Fouque">Denis Fouque</name></region><name sortKey="London, Gerard Michel" sort="London, Gerard Michel" uniqKey="London G" first="Gérard Michel" last="London">Gérard Michel London</name><name sortKey="Massy, Ziad A" sort="Massy, Ziad A" uniqKey="Massy Z" first="Ziad A" last="Massy">Ziad A. Massy</name><name sortKey="Rossignol, Patrick" sort="Rossignol, Patrick" uniqKey="Rossignol P" first="Patrick" last="Rossignol">Patrick Rossignol</name></country><country name="Allemagne"><noRegion><name sortKey="Heine, Gunnar H" sort="Heine, Gunnar H" uniqKey="Heine G" first="Gunnar H" last="Heine">Gunnar H. Heine</name></noRegion></country><country name="Turquie"><noRegion><name sortKey="Kanbay, Mehmet" sort="Kanbay, Mehmet" uniqKey="Kanbay M" first="Mehmet" last="Kanbay">Mehmet Kanbay</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Mallamaci, Francesca" sort="Mallamaci, Francesca" uniqKey="Mallamaci F" first="Francesca" last="Mallamaci">Francesca Mallamaci</name></noRegion><name sortKey="Zoccali, Carmine" sort="Zoccali, Carmine" uniqKey="Zoccali C" first="Carmine" last="Zoccali">Carmine Zoccali</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Ortiz, Alberto" sort="Ortiz, Alberto" uniqKey="Ortiz A" first="Alberto" last="Ortiz">Alberto Ortiz</name></region></country><country name="Pologne"><noRegion><name sortKey="Wiecek, Andrzej" sort="Wiecek, Andrzej" uniqKey="Wiecek A" first="Andrzej" last="Wiecek">Andrzej Wiecek</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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